Type: Package
Package: splinetrials
Title: Facilitate Clinical Trials Analysis Using Natural Cubic Splines
Version: 0.1.1.9001
Authors@R: c(
    person("Nik", "Krieger", , "nikkrieger@gmail.com", role = c("aut", "cre")),
    person("Daniel", "Sabanes Bove", , "daniel@rconis.com", role = "ctb"),
    person("Eli Lilly and Company", role = "cph")
  )
Description: Create mixed models with repeated measures using natural
        cubic splines applied to an observed continuous time variable,
        as described by Donohue et al. (2023) <doi:10.1002/pst.2285>.
        Iterate through multiple covariance structure types until one
        converges. Categorize observed time according to scheduled
        visits. Perform subgroup analyses.
License: Apache License (>= 2)
URL: https://github.com/NikKrieger/splinetrials,
        https://nikkrieger.github.io/splinetrials/
BugReports: https://github.com/NikKrieger/splinetrials/issues
Imports: car, cli, dplyr, emmeans, mmrm (>= 0.3.16), rlang, splines
Suggests: ggplot2, survival, testthat (>= 3.0.0)
Config/testthat/edition: 3
Encoding: UTF-8
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.3.3
Config/pak/sysreqs: cmake make libicu-dev
Repository: https://nikkrieger.r-universe.dev
Date/Publication: 2026-08-10 09:33:57 UTC
RemoteUrl: https://github.com/nikkrieger/splinetrials
RemoteRef: HEAD
RemoteSha: 46bee47457b7823fb5e6cc2681914f3437d333f7
NeedsCompilation: no
Packaged: 2026-10-09 10:15:34 UTC; root
Author: Nik Krieger [aut, cre],
  Daniel Sabanes Bove [ctb],
  Eli Lilly and Company [cph]
Maintainer: Nik Krieger <nikkrieger@gmail.com>